Coming along I-55 from the South West
When traveling along I-55N you want to make sure you stay on I-55 until you come to exit 293A for Cermak Road. Take this exit and make a left on to West Cermak Road. Follow this road down until you come to South Princeton Ave. Make a quick left on to Princeton and then a right on to West 23rd Street. Follow 23rd down and you will be smack dab in the middle of Chinatown.
Following I-94 East
As you follow I-94 East it might turn in to US-41 S depending on how far north you are. If it does switch to US-41 simply follow it along and it will turn back in to I-94 East. After you are on I-94 East you should follow it down until you come to exit 52C. Make a left on to Sout Union Avenue. Then make another left on to West 18th Street. Follow 18th down until you come to South Canal Street. Turn right on to Canal and then left on to 23rd Street. Now follow down 23rd until you have come in to Chinatown.
Coming from Indianapolis
You will be starting your journey from Indianapolis on West 10th Street heading toward Meridian. Make a left on to North Meridian Street and follow it until you come to 12th Street. Turn left on West 12th Street and merge on to the ramp heading toward Chicago. Make a left on to US-12 and follow it for around 2 miles. Turn right on to Broadway and then merge onto I-90 West. Follow I-90 West until you come to exit 53C. Take the exit and stay to the left to take the 22nd Street exit. Make a quick left on to West Cermak Road and follow it down until you get to South Princeton. Turn left on to South Princeton Avenue and then make a right on to West 23rd Street. Stay on 23rd until you are in Chinatown.